Phospholipidosis liver

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August undefined, 2024

WebScreen for drug-induced liver phospholipidosis and steatosis Cationic amphiphilic drugs are often associated with the induction of phospholipidosis, which is believed to be a precursor event to liver toxicity. WebPhospholipidosis appears to be a generalized systemic effect of cationic amphophilic compounds, such as AD. The cytotoxic pseudoalcoholic changes appear to be an independent phenomenon in susceptible patients, whom we speculate may have been unable or less able to metabolize AD through normal pathways.

Dysregulation of protein degradation pathways may mediate the liver …

WebOct 9, 2006 · Essentially, drug-induced phospholipidosis is characterized by phospholipid accumulation in affected tissue of which lung, liver, brain, kidney, cornea and others have … WebOct 1, 2014 · @article{osti_22439848, title = {Dysregulation of protein degradation pathways may mediate the liver injury and phospholipidosis associated with a cationic amphiphilic antibiotic drug}, author = {Mosedale, Merrie and Wu, Hong and Kurtz, C. Lisa and Schmidt, Stephen P. and Adkins, Karissa and Harrill, Alison H. and University of Arkansas for … bugs that live on your skin

An Immunohistochemical Approach to Differentiate Hepatic …

WebSep 1, 2013 · Ketoconazole was reported to cause phospholipidosis in the liver, lung and spleen (Whitehouse et al., 1994, Pakuts et al., 1990), but little is known about its effects on the kidneys in humans or animals. Thus, our findings about renal phospholipidosis are the first of their kind in ketoconazole-treated mice. WebMay 12, 2024 · Essential phospholipids can be incorporated as constituents of cell membranes of hepatocytes and thereby improve cellular function through an increase in … WebApr 27, 2009 · About 18 months after taking amiodarone, liver enzymes were noted to have increased and computed tomographic (CT) scanning of the abdomen showed a significant increase in the density of the liver without contrast medium, compared to that of the spleen and surrounding tissues (113 Hounsfield units (H), normal range of the liver is about … bugs that live under your skin

Drug-induced fatty liver disease: An overview of pathogenesis and ...

Phospholipidosis and Steatosis Assay IONTOX

Webation. For the hepatic phospholipidosis samples, archival parafﬁn-embedded tissue blocks were utilized from a 7-day dose-range ﬁnding study of an experimental compound that had cationic amphiphilic properties and caused dis-seminated phospholipidosis in dosed-rats as observed by light microscopic examination and conﬁrmed via electron ... WebPhospholipidosis and steatosis are two toxic effects, which course with overaccumulation of different classes of lipids in the liver. MS-based lipidomics has become a powerful tool … crossfit mats for garage gymWebIn this report, we describe the use of immunohistochemical staining for LAMP-2 (a lysosome-associated protein) and adipophilin (a protein that forms the membrane around … bugs that live on your eyelashes

"WebPhospholipidosis is most often detected in the lung, spIeen, thymus, lymph nodes, liver, bone marrow, adrenal gland, pituitary, ovaries and skin. The thalamus, medulla, spinal cord and intestinal ganglia are also affected in posaconazole treated dogs. Neuronal phospholipidosis was first observed in dogs in a twelve-month study. This " - Phospholipidosis liver

Phospholipidosis liver

Mucolipidoses National Institute of Neurological Disorders and Stroke

WebJan 16, 2015 · It possesses a significant side effect profile that includes hepatotoxicity and cirrhosis. Amiodarone-induced cirrhosis (AIC) is a rare and challenging diagnosis, and … WebJul 29, 2024 · It has been suggested that for every 10 cases of alanine aminotransferase (ALT) elevation (>10 times the upper limit of normal) in a clinical trial, there will be one case of more severe liver injury that develops once the drug is widely available [ 30,31 ].

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WebPhospholipidosis is characterized by the formation of intra-cytoplasmic lysosomal vacuoles containing whorls of material derivedfrom cellmembrane. The most commonlyaffectedcell types include monocytes, histiocytes of lymphoreticular organs, and hepatocytes. Phospholipidosis in the brain and peripheral ganglia is unusual and has been reported ... WebApr 5, 2013 · We present the first description of amiodarone toxicity in the liver without phospholipidosis or steatosis. In doing so, we will review the various effects of amiodarone toxicity in various organs. The patient is a young adult who had cardiac reconstruction as a child for transposition of the great vessels. A needle biopsy was taken due to elevated …

WebJul 29, 2024 · It has been suggested that for every 10 cases of alanine aminotransferase (ALT) elevation (>10 times the upper limit of normal) in a clinical trial, there will be one … WebApr 14, 2024 · We emphasize the importance of close monitoring of liver enzymes and evaluation of liver computed tomographic imaging as well as liver biopsy during treatment with amiodarone, and discontinuation should be considered when amiodarone-induced hepatotoxicity is suspected. ... which inhibits removal of lysosomal lipids and leads to …

WebJun 15, 2008 · Abstract. We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for diagnosis of hepatic phospholipidosis, we extracted 78 probe sets of rat hepatic genes from data of 5 drugs, amiodarone, amitriptyline, clomipramine, imipramine, and ketoconazole, which actually …

WebPhospholipidosis can develop in Kupffer cells within the liver and other organs as well. In most cases, phospholipidosis is reversible upon discontinuation of the drug or chemical. Sign in to download full-size image FIGURE 45.26. Electron micrograph of phospholipidosis within bile duct epithelium.

WebNov 29, 2024 · The long term effects of phospholipidosis are unknown. One cat in the 3X group had an enlarged thyroid/parathyroid gland found at necropsy. Higher liver weights occurred in cats in the 3X and 5X group that correlated with … bugs that look like a antWebDec 14, 2009 · In the authors’ experience, phospholipid accumulation in the lung or liver in the absence of other toxicities usually generates minimal to mild concern among regulatory officials. Phospholipidosis in neurons, the heart, or … bugs that live on the human bodyWebPhospholipidosis is an excessive intracellular accumulation of phospholipids and drug, which is normally reversible after discontinuation of drug treatment. Currently, it is … bugs that look like a roachWebNov 1, 2015 · Its hepatic toxicity is similar to amiodarone, histologically mimicking alcoholic steatohepatitis, associated with phospholipidosis. 111, 112 Pharmacologically, the drug impairs hepatic liver metabolism similarly to amiodarone, concentrating in the mitochondria, uncouples oxidative phosphorylation and inhibits ß-oxidation of fatty acids. bugs that look like a cockroachWebJan 20, 2024 · For example, excess storage of these molecules in nerve tissues can cause developmental disabilities, accumulation in the tissues of the spleen and liver can cause poor functioning of these vital organs, and excess storage in the bone marrow can damage bones, leading to skeletal deformities. crossfit mayhem daily wodWebPhospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues. [1] [2] [3] Certain cases may be triggered by medications. [4] … crossfit mayhem cookeville tnWebJun 29, 2012 · The liver plays a key role in fat metabolism, and excessive lipid accumulation in liver cells is characterised by a large spectrum of lesions, e.g., steatosis and phospholipidosis. bugs that look like a caterpillar