Peripherin 2

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August undefined, 2024

WebThis protein plays an important role in normal vision. Peripherin 2 is found in the retina, the light-sensitive tissue that lines the back of the eye. This protein is essential for the normal function of specialized cells called photoreceptors that detect light and color. Within these cells, peripherin 2 is involved in the formation and stability WebPeripherin-2, the product of the rdsgene, is a tetraspanin protein. In this study, we show that peripherin-2 forms a complex with melanoregulin (MREG), the product of the Mreglocus. Genetic studies suggest that MREG is involved in organelle biogenesis.

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WebDec 15, 2024 · December 15, 2024 Scott LaFee In healthy vision, a gene called PRPH2 provides instructions to make a protein called peripherin 2 (PRPH2), which plays a key role in the normal functioning of photoreceptors that detect light and color and which line the back of the eye. WebApr 21, 2024 · Mutations in the PRPH2 gene encoding the photoreceptor-specific protein PRPH2 (also known as peripherin-2 or rds) cause a broad range of autosomal dominant … girl nails pics

Peripherin-2 differentially interacts with cone opsins in outer ...

WebJun 15, 2016 · Peripherin-2 is a glycomembrane protein exclusively expressed in the light-sensing compartments of rod and cone photoreceptors designated as outer segments (OS). Mutations in peripherin-2 are associated with degenerative retinal diseases either affecting rod or cone photoreceptors. WebPeripherin-2 (UniProt: P15499; also known as Retinal degeneration slow protein) is encoded by the Prph2 (also known as Rds) gene (Gene ID: 19133) in murine species. Peripherin-2 … WebPeripherin-2 (also known as peripherin/rds), a photoreceptor specific tetraspanin protein, is required to maintain normal cell structure through its role in renewal processes requiring membrane fusion. It is the first tetraspanin fusogen and has been shown to directly mediate fusion between disk membranes and functions of eukaryotic cell structures

The Tetraspanin Protein Peripherin-2 Forms a Complex with …

WebNov 18, 2024 · Peripherin-2 (PRPH2) is one of the causative genes of inherited retinal dystrophy.While the gene is relatively common in Caucasians, reports from Asian ethnicities are limited. In the present study, we report 40 Japanese patients from 30 families with PRPH2-associated retinal dystrophy.We identified 17 distinct pathogenic or likely … Peripherin, first named such in 1984, was also known as 57 kDa neuronal intermediate filament prior to 1990. In 1987, a second distinct peripherally located retinal rod protein was also given the name peripherin. To distinguish between the two, this second protein is referred to peripherin 2 or peripherin/RDS (retinal degeneration slow) for its location and role in retinal disease. functions of endocrine glandWebPeripherin-2 is a critical factor in ocular disk morphogenesis and possibly functions as an adhesion molecule helping to stabilize and compact outer segment disks, to help maintain curvature of the rim. Peripherin-2 is expressed in the photoreceptors of the retina and in the rim of rod outer segment (ROS) disks. Peripherin-2 defects are found ... girl name alease

"WebPeripherin is an important protein that regulates the formation and renewal of photoreceptor disc outer segments. It is an integral membrane protein consisting of 346 amino acids that is localized to the rim region of rod and cone outer segments.60 It also complexes with a homologous protein called ROM1. " - Peripherin 2

Peripherin 2

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WebAug 28, 2014 · The peripherin-2 (PRPH2) gene encodes a photoreceptor-specific tetraspanin protein called peripherin-2/retinal degeneration slow (RDS), which is critical for the formation and maintenance of rod and cone outer segments. Over 90 different disease-causing mutations in PRPH2 have been identified, which … WebAug 28, 2014 · The peripherin-2 (PRPH2) gene encodes a photoreceptor-specific tetraspanin protein called peripherin-2/retinal degeneration slow (RDS), which is critical …

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WebJ:313794 Lewis TR, et al., Photoreceptor Disc Enclosure Is Tightly Controlled by Peripherin-2 Oligomerization. J Neurosci. 2024 Apr 21;41(16):3588-3596) Contributing Projects: … WebSep 14, 2016 · IFs expressed in neurons of the central and peripheral nervous systems are called neuronal intermediate filaments (NIFs) and include nestin, synemin, vimentin, α‐internexin, peripherin and neurofilaments (NFs) that are composed of three subunits, neurofilament light chain (NFL), neurofilament medium chain (NFM) and neurofilament …

WebMay 24, 2024 · The tetraspanin peripherin-2 is exclusively expressed in outer segments (OS), specific light detecting compartments of photoreceptors. Peripherin-2 forms homo- and heteromeric protein complexes in OS. WebPeripherin-2 is a multi-pass membrane glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It is localized to the photoreceptor disc rim region and is required for the initial formation and subsequent maintenance of …

WebDec 22, 2024 · PRPH2 is a protein encoded by the PRPH2 gene. PRPH2, sometimes referred to as peripherin/rds, peripherin-2, or RDS, is essential for the function and survival of rod and cone photoreceptors. PRPH2 sits in the membrane, or shell, of rod discs and cone lamellae, which are layered structures that make up the outer segments. WebPeripherin 2 (PRPH2), also known as RDS (retinal degeneration slow) is a photoreceptor specific glycoprotein which is essential for normal photoreceptor health and vision. PRPH2/RDS is necessary for the proper formation of both rod and cone photoreceptor outer segments, the organelle specialized for …

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functions of eeoWebJan 28, 2024 · Summary. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these … girl nail polish barbieWebNov 16, 2024 · Mammalian peripherin-2 (PRPH2) and rod outer segment membrane protein 1 (ROM1) are retina-specific tetraspanins that partake in the constant renewal of stacked membrane discs of photoreceptor cells that enable vision. Here, we present single-particle cryo-electron microscopy structures of solubilized PRPH2-ROM1 heterodimers and higher … functions of eukaryotic cell organellesWebNov 9, 2024 · PRPH2 and ROM1 are retina-specific members of the tetraspanin family. The members of this family, 33 in humans, are known as membrane organizers and are … girl named bodacious beautyWebDec 29, 2024 · Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1185) Abstract Peripherin 2 (also known as RDS/Prph2) is localized to the rims of rod and cone outer segment (OS) discs. The C-terminus of Prph2 is a critical functional domain, but its exact role is still unknown. functions of european commissionWebApr 28, 2024 · Healthy peripherin-2 protein is necessary for the proper functioning of photoreceptors called rods and cones, which are responsible for sight. Rods work at low levels of light, while cones allow... girl name bristol meaningWebPeripherin 2 (Prph2) is a photoreceptor-specific tetraspanin protein present in the outer segment (OS) rims of rod and cone photoreceptors. It shares many common features … girl name cadence meaning