Cisplatin sensitivity
WebFinally, an autophagy assay followed by western blotting was performed to study the effects of co-knockdown genes on cell autophagy in the presence and absence of cisplatin. … WebSep 30, 2014 · The lack of normal ERCC2 function may contribute to cisplatin sensitivity in urothelial cancer, and somatic ERCC2 mutation status may inform cisplatin-containing regimen usage in muscle-invasive urothelial carcinoma.
Cisplatin sensitivity
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WebThere is no relationship between the presence or severity of Cisplatin side effects and effectiveness of cisplatin. The following side effects are common(occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. ... USP14 levels were higher in DDP-resistant lung cancer compared to DDP-sensitive lung ...
WebMar 15, 2024 · The results indicated that URI knockdown increased the sensitivity of cells to cisplatin by inhibiting proliferation and promoting apoptosis. The levels of P-ATM, P-CHK2 and γH2AX were detected by Western blot. Increased levels of P-ATM, P-CHK2, and γH2AX were observed in cisplatin treated cells, indicating that cisplatin induced a DNA … WebThere are, however, contradictory reports suggesting that p53 signaling may sensitize cancer cells to cisplatin. Bunz and colleagues studied the role of p53 in cisplatin resistance in a colon cancer cell line in which both copies of p53 had been somatically disrupted (Bunz et …
WebJul 14, 2024 · Mechanismly, propofol enhances cisplatin sensitivity of NSCLC through miR-486-5p/RAP1-NF-κB axis. The finding provides a deeper understanding about the molecular mechanism of propofol in the platinum resistance of NSCLC, and might support the application of propofol in NSCLC chemotherapy. Materials and methods Cells culture WebMay 14, 2024 · Cisplatin is a highly effective chemotherapy regimen for individuals with BCa. However, cisplatin-based chemotherapy would be effective in less than 50% of BCa patients (Sagalowsky 2013 ). Cell-cycle regulation is one of the major determinants of cisplatin chemosensitivity (Yang et al. 2024; Borst et al. 2014 ).
WebFactors contributing to the observed cisplatin sensitivity include defective DNA damage repair and a hypersensitive apoptotic response to DNA damage. Nonetheless, around 10 …
WebMar 8, 2024 · XPV fibroblasts are sensitive to UV light and cisplatin but are corrected by transfection of POLHcDNA [1,13]. In this context, it is reasonable to postulate that human germline POLHvariants can alter the TLS activity and thus modify the susceptibility to toxic effects of UV and cisplatin in genetically affected individuals. software to stabilize shaky videoWebAug 1, 1996 · Purpose: Human glioma cell lines resistant (U373MGCP) and sensitive (U373MG) to cisplatin were used to evaluate the effect of cisplatin as a sensitizer to low dose rate irradiation (LDRI). Methods and materials: A cisplatin resistant glioma cell line U373MGCP was developed by chronic exposure of parental U373MG cells to cisplatin. . … slow playback in davinci resolveWebMar 25, 2024 · RRS1 silencing increased the sensitivity of MCF-7/DDP cells to cisplatin and inhibited cancer cell proliferation by blocking cell cycle distribution and enhancing apoptosis. AEG-1 (astrocyte elevated gene-1) promotes drug resistance by interfering with the ubiquitination and proteasomal degradation of MDR1 (multidrug resistance gene 1), … slow playback speed in windows media playerWebIdentification of Cisplatin-Sensitive and -Resistant Cell Lines. The sensitivity of cancer cell lines to drugs is mainly expressed in terms of the IC50 value, which refers to the … software to stack photosWebSensitivity to cisplatin in the different groups was measured as the IC 50 concentration after transfection. Growth inhibition rate of the A549 cells was 52.0% under the effect of cisplatin at an IC 50 concentration of 0.8 μg/mL but decreased to 37.6% after transfection with miR-195-5p-ASO. slow play brewery rock hillWebDec 2, 2024 · However, the underlying role and mechanism of circZNF609 in bladder cancer (BCa) development and cisplatin chemosensitivity were unknown. Quantitative real-time PCR (qRT-PCR) was applied to determine the expression of circZNF609, microRNA 1200 (miR-1200) and CDC25B in BCa cells and tissues. slow playback in premiere proWebA recent study indicated that NKX2-1 may modulate cellular sensitivity to cisplatin by modulating the β-catenin pathway through phosphorylation of AKT . We here … slow play at the open