Cisplatin resistance mechanism

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August undefined, 2024

WebUnfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation, and increased drug inactivation. WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using …

A highly annotated database of genes associated with platinum …

WebMar 3, 2008 · Resistance to platinum chemotherapy is multifactorial ( 2 – 6 ). There are five recognized DNA repair pathways that protect cellular DNA from injury: nucleotide excision repair, mismatch repair (MMR), double-strand break … WebOct 13, 2024 · An overview of the categories of platinum resistance mechanisms represented in the database is provided below. Regulation of drug entry, exit, accumulation, sequestration, and detoxification... diagnosis code for acute cholecystitis

Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin …

WebThe majority of cisplatin DNA lesions are repaired by the nucleotide excision repair (NER) system [ 79, 80]. One proposed mechanism for cisplatin resistance involves high expression of the high-mobility group box protein 1 (HMGB1) in TGCT cells [ 81]. WebCisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways … WebJul 1, 2001 · Knowledge of the mechanism of action of cisplatin has improved our understanding of resistance. Decerased intracellular concentration due to decreased … diagnosis code for adhd inattentive type

Targeted therapy for cisplatin‐resistant lung cancer via …

Molecular mechanisms of cisplatin resistance in bladder cancer

WebThe mechanism of action of cisplatin has been associated with ability to crosslink with the urine bases on the DNA to form DNA adducts, preventing repair of the DNA leading to DNA damage and subsequently induces apoptosis within cancer cells. WebNov 4, 2024 · These 13 genes identify a variety of cisplatin-resistance mechanisms including increased transport and detoxification of cisplatin, and mis-regulation of the epithelial to mesenchymal transition. Conclusions. We identified gene signatures in resistant TNBC subtypes indicative of mechanisms of cisplatin. Our results indicate … diagnosis code for add without hyperactivityWebJul 26, 2024 · Galuzzi et al. classified the cisplatin resistance mechanisms into four categories: (i) pre-target resistance, preventing the binding of cisplatin to DNA by reduced cellular accumulation or enhanced binding to cytoplasmic components; (ii) on-target resistance, by tolerating or repairing cisplatin-DNA adducts; (iii) post-target resistance, … cinfed 45211

"WebCisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes Ding-Wu Shen, Lynn M. Pouliot, Matthew D. Hall, and Michael M. Gottesman David R. Sibley, ASSOCIATE EDITOR Author informationCopyright and License informationDisclaimer " - Cisplatin resistance mechanism

Cisplatin resistance mechanism

Molecular mechanisms of cisplatin resistance Oncogene

WebSep 24, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms. Its most acceptable mechanism involves the formation of DNA–platinum adducts by interacting … WebApr 22, 2024 · Resistance to cisplatin, a platinum-based drug used as first-line chemotherapy treatment is a prominent example that has been extensively studied in …

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WebApr 13, 2024 · YTHDF1 interacts with the binding motif of GLS1 and increases glutamine uptake to enhance glutamine metabolism in cisplatin-resistant CRC cells. The inhibition of GLS1 leads to an increased sensitivity to cisplatin-induced cell death and YTHDF1 is also a potential target in overcoming resistant colon cancers . In gastric cancer, YTHDF2 … WebAug 24, 2024 · Components of tumor microenvironment reported to affect cisplatin resistance. These components can contribute to cisplatin resistance through decreased …

WebSilencing USP14 increased the tumor antagonistic action of DDP in A549 cisplatin-resistant (A549/DDP) cells, while USP14 overexpression decreased the antagonist … WebJan 9, 2024 · Mechanism analysis showed FAM83B interacted with APC to inhibit Wnt pathway activity, causing ovarian cancer cisplatin resistance. We also found FAM83B levels were negative with Wnt pathway ...

WebCisplatin resistance. Cisplatin combination chemotherapy is the cornerstone of treatment of many cancers. Initial platinum responsiveness is high, but the majority of cancer … WebJun 20, 2024 · We propose here a new mechanism of cisplatin resistance mediated by glutathione transferase (GST) P1-1, as a cisplatin-binding protein. Our results show that …

WebJan 10, 2014 · Here, we review the molecular mechanisms of cisplatin resistance. These include methods to reduce cisplatin bioavailability within a cell, and defects in the machinery that produces cell death following cisplatin-induced DNA damage. While overcoming these mechanisms is a potential therapeutic approach that can increase …

Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … diagnosis code for age related osteoporosisWebCisplatin DNA damage is repaired through four major mechanisms, including double-strand break repair (DSSR), mismatch repair (MMR), base excision repair (BER), and nucleotide excision repair (NER) ( Figure 2A … diagnosis code for afib with rvr icd 10WebJul 1, 2001 · Postulated mechanisms of resistance to cisplatin include the following: reduced intracellular accumulation of cisplatin which may arise because of decreased … c. infected treeWeb1 day ago · The resistance to cisplatin caused by MSH2 mutation can be partly rescued by proteasome inhibition (bortezomib), suggesting an adjuvant chemotherapeutic approach [39]. ... Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture. ACS CHEM BIOL, 17 … cinfed atm locations diagnosis code for allergic rhinitisWebNov 4, 2024 · These 13 genes identify a variety of cisplatin-resistance mechanisms including increased transport and detoxification of cisplatin, and mis-regulation of the … diagnosis code for acl tear right kneeWebJan 1, 2016 · Cisplatin is an alkylating agent capable of forming adducts with macromolecules, particularly with N7 atoms of purine nucleobases. This results in inter- and intra-strand DNA cross-links that bring induce cell cycle arrest mainly in the G 2 /M checkpoint ( Yuan et al., 2003 ). diagnosis code for alveoplasty